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Search Results for " peroxisome proliferator-activated receptor γ "

Targets

23

Compounds

7

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T15440 GSK376501A PPAR
GSK376501A is a selective and effective modulator of peroxisome proliferator-activated receptor γ (PPARγ) for the study of type 2 diabetes.
T16022 Arhalofenate JNJ 39659100,MBX 102 PPAR
Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.
T8780 AMG131 INT-131,AMG-131,CHS 131 PPAR
AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for the treatment of type 2 diabetes mellitus (non-insulin depende...
T69146 Suksdorfin PPAR
Suksdorfin has hypoglycemic effects, promotes adipocyte differentiation and enhances lipocalin production, activates peroxisome proliferator-activated receptor gamma (PPARγ), promotes insulin-dependent glucose uptake by ...
T28354 Peliglitazar BMS-426707-1,BMS 42670701,BMS 426707-01
Peliglitazar is a activator of α/γ peroxisome proliferator-activated receptor.
T33415 MK 0767 MK0767,MK-0767
MK 0767 is a dual peroxisome proliferator-activated receptor (PPAR) α/γ agonist that has been investigated as a potential treatment for type 2 diabetes and dyslipidemia.
T68245 PA-082
PA-082 is a Novel partial agonist of peroxisome proliferator-activated receptor-γ (PPARγ), recruiting PPARγ-coactivator-1α, preventing triglyceride accumulation, and potentiating insulin signaling in vitro.
T37579 GW 1929 hydrochloride
Highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and tr...
T68000 MK 0533
Mk-0533 is a selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus.
T37827 CAY10506 CAY10506
Anti-diabetic drugs of the thiazolidinedione (TZD) structural class as well as α-lipoic acid activate peroxisome proliferator-activated receptor γ (PPARγ), a nuclear transcription factor that controls glucose metabolism ...
T28589 Ro 41-5253 Ro-41-5253,Ro 415253 Apoptosis , Retinoid Receptor
Ro 41-5253 is an orally active RARα antagonist, ligand and partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ. It exhibits antitumor activity, inhibits proliferation and induces apoptosis in MCF-7 and...
T28542 Rivoglitazone HCl CI-1037,CI1037,CS011,CS-011,CI 1037
Rivoglitazone, also known as CI-1037; CS-011; DE-101; R-119702; Rivo, is a peroxisome proliferator-activated receptor γ agonist (PARPγ agonist) potentially for the treatment of type 2 diabetes. Rivoglitazone has been sho...
T73519 FX-909
FX-909 is a covalent peroxisome proliferator-activated receptor gamma ( PPARG ) inverse agonist. FX-909 can be used for the research of cancer .
T62576 Darglitazone Sodium
Darglitazone Sodium is a thiazolidinedione, a selective, orally active PPAR-γ (peroxisome proliferator-activated receptor) agonist, which can be used in the study of type II diabetes as it effectively controls glucose an...
T71284 Glimepiride urethane
Glimepiride urethane is a third generation sulfonylurea compound, which increases the release of insulin from pancreatic beta cells. In addition, glimepiride increases the activity of intracellular insulin receptors. Gli...
T13483 RP 54275 2-Octadecyl-1H-indole-5-carboxylic acid Others
RP 54275 is a naturally occurring fatty acid derivative, a new cholesterol-lowering compound. It activates the peroxisome proliferator-activated receptor gamma (PPARγ) pathway, which is involved in the regulation of lipi...
T83882 XY-4
XY-4, a derivative of 1-palmitoyl lysophosphatidic acid (1-palmitoyl LPA094) and an agonist of peroxisome proliferator-activated receptor γ (PPARγ), effectively induces reporter gene expression in RAW 264.7 macrophages h...
T69671 SR1903 TFA
SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated rec...
T37787 10-Nitrolinoleic acid
10-Nitrolinoleate is the product of nitration of linoleate by NO-derived reactive species. Other nitrolinoleates detected in human plasma and urine include 9-, 12-, and 13-nitrolinoleate. Nitrolinoleates activate peroxis...
T35638 SR 1903
SR 1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR).1 It is an inverse agonist of RORγ (IC50 = ~100 nM in a cell-based reporter assay) and an agonist of LXR. It al...
T83879 1-Arachidoyl Lysophosphatidic Acid sodium 1-Arachidoyl LPA,LPA(20:0),1-Eicosanoyl-Lysophosphatidic Acid
1-Arachidoyl lysophosphatidic acid (1-arachidoyl LPA), a glycerophospholipid with arachidic acid at the sn-1 position, functions as an agonist for lysophosphatidic acid receptor 1 (LPA1). It effectively induces calcium m...
T35813 CAY10592
Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharm...
T35800 MD001
MD001 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ.1 It binds to PPARα and PPARγ (Kds = 9.55 and 0.14 μM, respectively) but does not bind to PPARβ/δ at concentrations up to 500 μM. ...
Cat No. Product Name Synonyms Targets
T1633 β-Carotene Carotaben,Beta-Carotene,Provitamin A Apoptosis , ROS , Endogenous Metabolite
β-Carotene (Provitamin A) is a naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities. As an anti-oxidant, beta carotene...
T4S0800 Demethyleneberberine P450 , NOS , NF-κB , HIF , AMPK
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1,...
T2915 Bardoxolone RTA 401,CDDO Others , Nrf2
Bardoxolone (CDDO) is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM. By supp...
TN2601 12-O-Methylcarnosic acid Reductase
12-O-Methylcarnosic acid is a diterpene carnosic acid isolated from Salvia microphylla, is an active constituent of 5α-Reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid has Antioxidant activity...
TN4860 Pueroside B COX , PPAR
Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-converting enzyme (ACE), hydroxymethylglutaryl coenzyme A rece...
T75611 Tibesaikosaponin V
Tibesaikosaponin V (TKV), a triterpene diglycoside isolated from the methanol extract of Bupleurum chinense DC roots, effectively inhibits lipid accumulation and triacylglycerol content in adipocytes without inducing cyt...
T83915 Norbixin hydrate
Norbixin, a carotenoid found in B. orellana, exhibits various biological activities including binding to the peroxisome proliferator-activated receptor γ (PPARγ) with a Ki of 1.15 µM in a cell-free assay. At a dosage of ...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02575 PPAR gamma/PPARG Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling even...
TargetMol